Drug interactions
Chlorpromazine + Selinexor
Severity: Moderate
Chlorpromazine and Selinexor: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Selinexor commonly causes dizziness, confusion and other neurological effects, and chlorpromazine is sedating and can cause similar symptoms. Using them together may worsen cognitive impairment and raise the risk of falls.
What this interaction means in plain words
Chlorpromazine and Selinexor can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Chlorpromazine belongs to Central Nervous System; Selinexor belongs to Oncology.
Why it happens
Additive central nervous system effects; no specific pharmacokinetic mechanism is established.
What to do
Monitor for dizziness, confusion and sedation, and counsel the patient on fall precautions. Reduce the chlorpromazine dose or choose a less sedating agent if neurological symptoms develop.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Chlorpromazine
- Chlorpromazine + Dofetilide Contraindicated
- Chlorpromazine + Dronedarone Contraindicated
- Chlorpromazine + Droperidol Contraindicated
- Chlorpromazine + Ibutilide Contraindicated
- Chlorpromazine + Metrizamide Contraindicated
- Chlorpromazine + Panobinostat Contraindicated
Other interactions of Selinexor
- Aldesleukin + Selinexor Moderate
- Alprazolam + Selinexor Moderate
- Amitriptyline + Selinexor Moderate
- Amobarbital + Selinexor Moderate
- Aripiprazole + Selinexor Moderate
- Asenapine + Selinexor Moderate
Frequently asked questions
Can I take Chlorpromazine with Selinexor?
MediHelp rates the interaction as moderate. Chlorpromazine and Selinexor can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Selinexor commonly causes dizziness, confusion and other neurological effects, and chlorpromazine is sedating and can cause similar symptoms. Using them together may worsen cognitive impairment and raise the risk of falls.
How serious is the interaction between Chlorpromazine and Selinexor?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for dizziness, confusion and sedation, and counsel the patient on fall precautions. Reduce the chlorpromazine dose or choose a less sedating agent if neurological symptoms develop.
What other medicines interact with Chlorpromazine?
MediHelp also lists interactions of Chlorpromazine with, for example, Dofetilide, Dronedarone, Droperidol. The full list is on the Chlorpromazine page.
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