Drug interactions
Chlorpromazine + Solifenacin
Severity: Moderate
Chlorpromazine and Solifenacin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can prolong the QT interval, and chlorpromazine also adds antimuscarinic burden. Together they may raise the risk of torsades de pointes, particularly with electrolyte disturbances or heart disease. Additive anticholinergic effects such as constipation, urinary retention and confusion may also occur.
What this interaction means in plain words
Chlorpromazine and Solifenacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Chlorpromazine belongs to Central Nervous System; Solifenacin belongs to Genitourinary.
Why it happens
Additive pharmacodynamic QT prolongation (hERG blockade) plus additive antimuscarinic effects.
What to do
Obtain a baseline ECG and correct potassium and magnesium before combining. Monitor the QTc and anticholinergic effects, and consider an alternative bladder agent in patients with other QT risk factors.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Solifenacin
Other interactions of Chlorpromazine
- Chlorpromazine + Dofetilide Contraindicated
- Chlorpromazine + Dronedarone Contraindicated
- Chlorpromazine + Droperidol Contraindicated
- Chlorpromazine + Ibutilide Contraindicated
- Chlorpromazine + Metrizamide Contraindicated
- Chlorpromazine + Panobinostat Contraindicated
Frequently asked questions
Can I take Chlorpromazine with Solifenacin?
MediHelp rates the interaction as moderate. Chlorpromazine and Solifenacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs can prolong the QT interval, and chlorpromazine also adds antimuscarinic burden. Together they may raise the risk of torsades de pointes, particularly with electrolyte disturbances or heart disease. Additive anticholinergic effects such as constipation, urinary retention and confusion may also occur.
How serious is the interaction between Chlorpromazine and Solifenacin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG and correct potassium and magnesium before combining. Monitor the QTc and anticholinergic effects, and consider an alternative bladder agent in patients with other QT risk factors.
What other medicines interact with Solifenacin?
MediHelp also lists interactions of Solifenacin with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Solifenacin page.
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