Drug interactions
Chlorpromazine + Vemurafenib
Severity: Major
Chlorpromazine and Vemurafenib: major interaction.
Last updated Sources: UK SmPC
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Vemurafenib can cause concentration-dependent QT prolongation, and chlorpromazine adds to this effect. The combination raises the risk of torsades de pointes.
What this interaction means in plain words
Chlorpromazine and Vemurafenib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Chlorpromazine belongs to Central Nervous System; Vemurafenib belongs to Oncology.
Why it happens
Additive QT prolongation; vemurafenib is also a CYP1A2 inhibitor and may modestly affect chlorpromazine metabolism.
What to do
Avoid the combination where possible; otherwise obtain baseline and periodic ECGs and correct electrolytes. Interrupt or reduce vemurafenib if QTc becomes markedly prolonged.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Chlorpromazine
- Chlorpromazine + Dofetilide Contraindicated
- Chlorpromazine + Dronedarone Contraindicated
- Chlorpromazine + Droperidol Contraindicated
- Chlorpromazine + Ibutilide Contraindicated
- Chlorpromazine + Metrizamide Contraindicated
- Chlorpromazine + Panobinostat Contraindicated
Other interactions of Vemurafenib
Frequently asked questions
Can I take Chlorpromazine with Vemurafenib?
MediHelp rates the interaction as major. Chlorpromazine and Vemurafenib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Vemurafenib can cause concentration-dependent QT prolongation, and chlorpromazine adds to this effect. The combination raises the risk of torsades de pointes.
How serious is the interaction between Chlorpromazine and Vemurafenib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible; otherwise obtain baseline and periodic ECGs and correct electrolytes. Interrupt or reduce vemurafenib if QTc becomes markedly prolonged.
What other medicines interact with Chlorpromazine?
MediHelp also lists interactions of Chlorpromazine with, for example, Dofetilide, Dronedarone, Droperidol. The full list is on the Chlorpromazine page.
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