Drug interactions
Chlorpropamide + Empagliflozin
Severity: Moderate
Chlorpropamide and Empagliflozin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Empagliflozin lowers blood glucose independently of insulin, so adding it to a sulfonylurea increases the likelihood of hypoglycemia. Chlorpropamide has a very long half-life, which makes any hypoglycemia prolonged.
What this interaction means in plain words
Chlorpropamide and Empagliflozin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Chlorpropamide belongs to Endocrine; Empagliflozin belongs to Endocrine.
Why it happens
Additive glucose-lowering effects through insulin secretion stimulation (sulfonylurea) and increased urinary glucose excretion (SGLT2 inhibition).
What to do
Consider reducing the chlorpropamide dose when starting empagliflozin and monitor blood glucose closely. Educate the patient on recognizing and treating hypoglycemia.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Chlorpropamide
Other interactions of Empagliflozin
- Amiloride + Empagliflozin Moderate
- Amlodipine-hydrochlorothiazide-valsartan + Empagliflozin Moderate
- Amlodipine-olmesartan-hydrochlorothiazide + Empagliflozin Moderate
- Atenolol-chlorthalidone + Empagliflozin Moderate
- Azilsartan-chlorthalidone + Empagliflozin Moderate
- Bendroflumethiazide + Empagliflozin Moderate
Frequently asked questions
Can I take Chlorpropamide with Empagliflozin?
MediHelp rates the interaction as moderate. Chlorpropamide and Empagliflozin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Empagliflozin lowers blood glucose independently of insulin, so adding it to a sulfonylurea increases the likelihood of hypoglycemia. Chlorpropamide has a very long half-life, which makes any hypoglycemia prolonged.
How serious is the interaction between Chlorpropamide and Empagliflozin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider reducing the chlorpropamide dose when starting empagliflozin and monitor blood glucose closely. Educate the patient on recognizing and treating hypoglycemia.
What other medicines interact with Chlorpropamide?
MediHelp also lists interactions of Chlorpropamide with, for example, Ethanol, Exenatide, Insulin degludec-insulin aspart. The full list is on the Chlorpropamide page.
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