Drug interactions
Chlorthalidone + Empagliflozin
Severity: Moderate
Chlorthalidone and Empagliflozin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs promote diuresis, so combined use can cause volume depletion, hypotension and acute kidney injury, particularly in elderly patients or those with low baseline blood pressure.
What this interaction means in plain words
Chlorthalidone and Empagliflozin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Chlorthalidone belongs to Cardiovascular; Empagliflozin belongs to Endocrine.
Why it happens
Additive osmotic and natriuretic diuresis from SGLT2 inhibition and thiazide-type diuretic action.
What to do
Assess volume status and renal function before and after starting empagliflozin. Consider reducing the diuretic dose in patients at risk of hypovolemia.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Chlorthalidone
Other interactions of Empagliflozin
- Amiloride + Empagliflozin Moderate
- Amlodipine-hydrochlorothiazide-valsartan + Empagliflozin Moderate
- Amlodipine-olmesartan-hydrochlorothiazide + Empagliflozin Moderate
- Atenolol-chlorthalidone + Empagliflozin Moderate
- Azilsartan-chlorthalidone + Empagliflozin Moderate
- Bendroflumethiazide + Empagliflozin Moderate
Frequently asked questions
Can I take Chlorthalidone with Empagliflozin?
MediHelp rates the interaction as moderate. Chlorthalidone and Empagliflozin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs promote diuresis, so combined use can cause volume depletion, hypotension and acute kidney injury, particularly in elderly patients or those with low baseline blood pressure.
How serious is the interaction between Chlorthalidone and Empagliflozin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Assess volume status and renal function before and after starting empagliflozin. Consider reducing the diuretic dose in patients at risk of hypovolemia.
What other medicines interact with Chlorthalidone?
MediHelp also lists interactions of Chlorthalidone with, for example, Amifostine, Atenolol-chlorthalidone, Candesartan-hydrochlorothiazide. The full list is on the Chlorthalidone page.
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