Drug interactions
Ciclesonide + Lenacapavir
Severity: Moderate
Ciclesonide and Lenacapavir: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lenacapavir is a moderate CYP3A4 inhibitor and may modestly increase ciclesonide exposure. Because of its long half-life after subcutaneous dosing, the inhibitory effect can persist for months.
What this interaction means in plain words
Ciclesonide and Lenacapavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ciclesonide belongs to Respiratory; Lenacapavir belongs to Anti Virals.
Why it happens
Moderate CYP3A4 inhibition by lenacapavir decreases ciclesonide metabolism.
What to do
Monitor for systemic corticosteroid effects with long-term use, including after lenacapavir has been stopped. Use the lowest effective ciclesonide dose.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ciclesonide
- Ciclesonide + Ritonavir Major
- Apalutamide + Ciclesonide Moderate
- Atazanavir + Ciclesonide Moderate
- Ceritinib + Ciclesonide Moderate
- Ciclesonide + Clarithromycin Moderate
- Ciclesonide + Cobicistat Moderate
Other interactions of Lenacapavir
- Apalutamide + Lenacapavir Contraindicated
- Carbamazepine + Lenacapavir Contraindicated
- Enzalutamide + Lenacapavir Contraindicated
- Flibanserin + Lenacapavir Contraindicated
- Lenacapavir + Phenytoin Contraindicated
- Lenacapavir + Rifampicin Contraindicated
Frequently asked questions
Can I take Ciclesonide with Lenacapavir?
MediHelp rates the interaction as moderate. Ciclesonide and Lenacapavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lenacapavir is a moderate CYP3A4 inhibitor and may modestly increase ciclesonide exposure. Because of its long half-life after subcutaneous dosing, the inhibitory effect can persist for months.
How serious is the interaction between Ciclesonide and Lenacapavir?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for systemic corticosteroid effects with long-term use, including after lenacapavir has been stopped. Use the lowest effective ciclesonide dose.
What other medicines interact with Ciclesonide?
MediHelp also lists interactions of Ciclesonide with, for example, Ritonavir, Apalutamide, Atazanavir. The full list is on the Ciclesonide page.
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