Drug interactions
Ciclesonide + Mifepristone
Severity: Moderate
Ciclesonide and Mifepristone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Mifepristone inhibits CYP3A4 and may raise systemic levels of ciclesonide's active metabolite. Mifepristone also blocks glucocorticoid receptors, so the net clinical effect is unpredictable.
What this interaction means in plain words
Ciclesonide and Mifepristone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ciclesonide belongs to Respiratory; Mifepristone belongs to Endocrine.
Why it happens
CYP3A4 inhibition reduces ciclesonide clearance, while glucocorticoid receptor antagonism by mifepristone may counteract steroid effects.
What to do
Monitor asthma control and for signs of corticosteroid excess or reduced steroid efficacy. Adjust the ciclesonide dose according to clinical response.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ciclesonide
- Ciclesonide + Ritonavir Major
- Apalutamide + Ciclesonide Moderate
- Atazanavir + Ciclesonide Moderate
- Ceritinib + Ciclesonide Moderate
- Ciclesonide + Clarithromycin Moderate
- Ciclesonide + Cobicistat Moderate
Other interactions of Mifepristone
- Apixaban + Mifepristone Contraindicated
- Argatroban + Mifepristone Contraindicated
- Cisapride + Mifepristone Contraindicated
- Cortisone + Mifepristone Contraindicated
- Cyclosporin + Mifepristone Contraindicated
- Dabigatran etexilate + Mifepristone Contraindicated
Frequently asked questions
Can I take Ciclesonide with Mifepristone?
MediHelp rates the interaction as moderate. Ciclesonide and Mifepristone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Mifepristone inhibits CYP3A4 and may raise systemic levels of ciclesonide's active metabolite. Mifepristone also blocks glucocorticoid receptors, so the net clinical effect is unpredictable.
How serious is the interaction between Ciclesonide and Mifepristone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor asthma control and for signs of corticosteroid excess or reduced steroid efficacy. Adjust the ciclesonide dose according to clinical response.
What other medicines interact with Ciclesonide?
MediHelp also lists interactions of Ciclesonide with, for example, Ritonavir, Apalutamide, Atazanavir. The full list is on the Ciclesonide page.
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