Drug interactions
Cimetidine + Dexmethylphenidate
Severity: Minor
Cimetidine and Dexmethylphenidate: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Extended-release dexmethylphenidate formulations can have altered release profiles when gastric pH rises, as with acid-reducing drugs. This may change the onset or peak exposure of the dose.
What this interaction means in plain words
Cimetidine and Dexmethylphenidate have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Cimetidine belongs to Gastrointestinal Tract; Dexmethylphenidate belongs to Central Nervous System.
Why it happens
Increased gastric pH may alter pH-dependent release from some extended-release formulations.
What to do
Monitor clinical response and tolerability when starting or stopping cimetidine with an extended-release product; consider an immediate-release formulation if response is erratic.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Cimetidine
- Cimetidine + Dofetilide Contraindicated
- Cimetidine + Fezolinetant Contraindicated
- Alfentanil + Cimetidine Major
- Atazanavir + Cimetidine Major
- Carmustine + Cimetidine Major
- Cimetidine + Citalopram Major
Other interactions of Dexmethylphenidate
- Dexmethylphenidate + Isocarboxazid Contraindicated
- Dexmethylphenidate + Linezolid Contraindicated
- Dexmethylphenidate + Phenelzine Contraindicated
- Dexmethylphenidate + Procarbazine Contraindicated
- Dexmethylphenidate + Rasagiline Contraindicated
- Dexmethylphenidate + Safinamide Contraindicated
Frequently asked questions
Can I take Cimetidine with Dexmethylphenidate?
MediHelp rates the interaction as minor. Cimetidine and Dexmethylphenidate have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Extended-release dexmethylphenidate formulations can have altered release profiles when gastric pH rises, as with acid-reducing drugs. This may change the onset or peak exposure of the dose.
How serious is the interaction between Cimetidine and Dexmethylphenidate?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor clinical response and tolerability when starting or stopping cimetidine with an extended-release product; consider an immediate-release formulation if response is erratic.
What other medicines interact with Cimetidine?
MediHelp also lists interactions of Cimetidine with, for example, Dofetilide, Fezolinetant, Alfentanil. The full list is on the Cimetidine page.
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