Drug interactions
Cimetidine + Silodosin
Severity: Minor
Cimetidine and Silodosin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cimetidine may modestly increase silodosin exposure, potentially causing more orthostatic hypotension and dizziness. A strong CYP3A4 inhibitor is contraindicated, but cimetidine is much weaker.
What this interaction means in plain words
Cimetidine and Silodosin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Cimetidine belongs to Gastrointestinal Tract; Silodosin belongs to Genitourinary.
Why it happens
Cimetidine weakly inhibits CYP3A4 and may affect P-glycoprotein, slightly reducing silodosin clearance.
What to do
No dose adjustment is generally required; counsel patients about dizziness on standing.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Cimetidine
- Cimetidine + Dofetilide Contraindicated
- Cimetidine + Fezolinetant Contraindicated
- Alfentanil + Cimetidine Major
- Atazanavir + Cimetidine Major
- Carmustine + Cimetidine Major
- Cimetidine + Citalopram Major
Other interactions of Silodosin
- Atazanavir + Silodosin Contraindicated
- Conivaptan + Silodosin Contraindicated
- Darunavir + Silodosin Contraindicated
- Fosamprenavir + Silodosin Contraindicated
- Indinavir + Silodosin Contraindicated
- Itraconazole + Silodosin Contraindicated
Frequently asked questions
Can I take Cimetidine with Silodosin?
MediHelp rates the interaction as minor. Cimetidine and Silodosin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Cimetidine may modestly increase silodosin exposure, potentially causing more orthostatic hypotension and dizziness. A strong CYP3A4 inhibitor is contraindicated, but cimetidine is much weaker.
How serious is the interaction between Cimetidine and Silodosin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is generally required; counsel patients about dizziness on standing.
What other medicines interact with Cimetidine?
MediHelp also lists interactions of Cimetidine with, for example, Dofetilide, Fezolinetant, Alfentanil. The full list is on the Cimetidine page.
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