Drug interactions
Cimetidine + Vismodegib
Severity: Minor
Cimetidine and Vismodegib: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Agents that raise gastric pH may lower the solubility of vismodegib and so reduce its absorption. The effect on antitumor efficacy has not been established. Clinical relevance is uncertain.
What this interaction means in plain words
Cimetidine and Vismodegib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Cimetidine belongs to Gastrointestinal Tract; Vismodegib belongs to Oncology.
Why it happens
Increased gastric pH alters pH-dependent vismodegib solubility and may reduce its oral bioavailability.
What to do
No routine adjustment is required; monitor tumor response if acid suppression is long term. Stop the acid suppressant if there is unexplained loss of response.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Cimetidine
- Cimetidine + Dofetilide Contraindicated
- Cimetidine + Fezolinetant Contraindicated
- Alfentanil + Cimetidine Major
- Atazanavir + Cimetidine Major
- Carmustine + Cimetidine Major
- Cimetidine + Citalopram Major
Other interactions of Vismodegib
- Dexlansoprazole + Vismodegib Moderate
- Esomeprazole + Vismodegib Moderate
- Famotidine + Vismodegib Moderate
- Omeprazole + Vismodegib Moderate
- Pantoprazole + Vismodegib Moderate
- Aluminum hydroxide + Vismodegib Minor
Frequently asked questions
Can I take Cimetidine with Vismodegib?
MediHelp rates the interaction as minor. Cimetidine and Vismodegib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Agents that raise gastric pH may lower the solubility of vismodegib and so reduce its absorption. The effect on antitumor efficacy has not been established. Clinical relevance is uncertain.
How serious is the interaction between Cimetidine and Vismodegib?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment is required; monitor tumor response if acid suppression is long term. Stop the acid suppressant if there is unexplained loss of response.
What other medicines interact with Cimetidine?
MediHelp also lists interactions of Cimetidine with, for example, Dofetilide, Fezolinetant, Alfentanil. The full list is on the Cimetidine page.
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