Drug interactions
Cinacalcet + Posaconazole
Severity: Moderate
Cinacalcet and Posaconazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Posaconazole can increase cinacalcet exposure, though cinacalcet is cleared by several pathways including CYP2D6. This may cause hypocalcemia and gastrointestinal effects.
What this interaction means in plain words
Cinacalcet and Posaconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cinacalcet belongs to Miscellaneous; Posaconazole belongs to Anti Fungals.
Why it happens
Posaconazole inhibits CYP3A4, one of the enzymes metabolizing cinacalcet.
What to do
Monitor serum calcium and PTH and adjust the cinacalcet dose as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Posaconazole
- Artemether + Posaconazole Contraindicated
- Avanafil + Posaconazole Contraindicated
- Cobimetinib + Posaconazole Contraindicated
- Conivaptan + Posaconazole Contraindicated
- Dihydroergotamine intranasal + Posaconazole Contraindicated
- Dihydroergotamine + Posaconazole Contraindicated
Other interactions of Cinacalcet
- Cinacalcet + Etelcalcetide Contraindicated
- Cinacalcet + Eliglustat Major
- Cinacalcet + Metoclopramide Major
- Cinacalcet + Metoclopramide intranasal Major
- Cinacalcet + Tamoxifen Major
- Abiraterone + Cinacalcet Moderate
Frequently asked questions
Can I take Cinacalcet with Posaconazole?
MediHelp rates the interaction as moderate. Cinacalcet and Posaconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Posaconazole can increase cinacalcet exposure, though cinacalcet is cleared by several pathways including CYP2D6. This may cause hypocalcemia and gastrointestinal effects.
How serious is the interaction between Cinacalcet and Posaconazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum calcium and PTH and adjust the cinacalcet dose as needed.
What other medicines interact with Posaconazole?
MediHelp also lists interactions of Posaconazole with, for example, Artemether, Avanafil, Cobimetinib. The full list is on the Posaconazole page.
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