Drug interactions
Cinnarizine + Prochlorperazine
Severity: Moderate
Cinnarizine and Prochlorperazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cinnarizine is a sedating antihistamine and calcium channel blocker that can cause drowsiness and, rarely, extrapyramidal symptoms. Combined with prochlorperazine, sedation and parkinsonian effects may be additive.
What this interaction means in plain words
Cinnarizine and Prochlorperazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cinnarizine belongs to Respiratory; Prochlorperazine belongs to Central Nervous System.
Why it happens
Additive sedative antihistaminic effects and additive dopamine receptor blockade.
What to do
Monitor for oversedation and extrapyramidal symptoms, especially in older patients. Avoid combined use in patients with Parkinson disease.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Prochlorperazine
- Dronedarone + Prochlorperazine Contraindicated
- Ibutilide + Prochlorperazine Contraindicated
- Nilotinib + Prochlorperazine Contraindicated
- Pimozide + Prochlorperazine Contraindicated
- Prochlorperazine + Thioridazine Contraindicated
- Amiodarone + Prochlorperazine Major
Other interactions of Cinnarizine
- Alprazolam + Cinnarizine Moderate
- Amitriptyline + Cinnarizine Moderate
- Amobarbital + Cinnarizine Moderate
- Aripiprazole + Cinnarizine Moderate
- Azelastine-fluticasone + Cinnarizine Moderate
- Azelastine + Cinnarizine Moderate
Frequently asked questions
Can I take Cinnarizine with Prochlorperazine?
MediHelp rates the interaction as moderate. Cinnarizine and Prochlorperazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cinnarizine is a sedating antihistamine and calcium channel blocker that can cause drowsiness and, rarely, extrapyramidal symptoms. Combined with prochlorperazine, sedation and parkinsonian effects may be additive.
How serious is the interaction between Cinnarizine and Prochlorperazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for oversedation and extrapyramidal symptoms, especially in older patients. Avoid combined use in patients with Parkinson disease.
What other medicines interact with Prochlorperazine?
MediHelp also lists interactions of Prochlorperazine with, for example, Dronedarone, Ibutilide, Nilotinib. The full list is on the Prochlorperazine page.
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