Drug interactions
Ciprofloxacin + Ertugliflozin-sitagliptin
Severity: Moderate
Ciprofloxacin and Ertugliflozin-sitagliptin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fluoroquinolones such as ciprofloxacin can cause both hypoglycemia and hyperglycemia in patients treated with antidiabetic drugs. Sitagliptin and ertugliflozin carry lower hypoglycemia risk than insulin or sulfonylureas, but glucose disturbances can still occur.
What this interaction means in plain words
Ciprofloxacin and Ertugliflozin-sitagliptin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ciprofloxacin belongs to Anti Bacterial; Ertugliflozin-sitagliptin belongs to Endocrine.
Why it happens
Pharmacodynamic effect of fluoroquinolones on pancreatic insulin release and glucose homeostasis.
What to do
Monitor blood glucose during the antibiotic course and educate the patient on symptoms of dysglycemia. Stop ciprofloxacin and use an alternative antibiotic if significant disturbance occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ertugliflozin-sitagliptin
Other interactions of Ciprofloxacin
- Agomelatine + Ciprofloxacin Contraindicated
- Ciprofloxacin + Fezolinetant Contraindicated
- Ciprofloxacin + Thioridazine Contraindicated
- Ciprofloxacin + Tizanidine Contraindicated
- Ciprofloxacin + Vandetanib Contraindicated
- Alosetron + Ciprofloxacin Major
Frequently asked questions
Can I take Ciprofloxacin with Ertugliflozin-sitagliptin?
MediHelp rates the interaction as moderate. Ciprofloxacin and Ertugliflozin-sitagliptin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fluoroquinolones such as ciprofloxacin can cause both hypoglycemia and hyperglycemia in patients treated with antidiabetic drugs. Sitagliptin and ertugliflozin carry lower hypoglycemia risk than insulin or sulfonylureas, but glucose disturbances can still occur.
How serious is the interaction between Ciprofloxacin and Ertugliflozin-sitagliptin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose during the antibiotic course and educate the patient on symptoms of dysglycemia. Stop ciprofloxacin and use an alternative antibiotic if significant disturbance occurs.
What other medicines interact with Ertugliflozin-sitagliptin?
MediHelp also lists interactions of Ertugliflozin-sitagliptin with, for example, Albiglutide, Aripiprazole, Asenapine. The full list is on the Ertugliflozin-sitagliptin page.
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