Drug interactions
Cisapride + Ethinyl estradiol-drospirenone
Severity: Minor
Cisapride and Ethinyl estradiol-drospirenone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cisapride is a sensitive CYP3A4 substrate with QT-prolongation risk, so any rise in levels is of concern. Drospirenone is not an established CYP3A4 inhibitor, so the practical risk from this contraceptive is likely low, but cisapride use is heavily restricted.
What this interaction means in plain words
Cisapride and Ethinyl estradiol-drospirenone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Cisapride belongs to Gastrointestinal Tract; Ethinyl estradiol-drospirenone belongs to Endocrine.
Why it happens
Theoretical weak CYP3A4 inhibition raising cisapride levels; not clinically established.
What to do
Cisapride is available only under restricted access; if used, check the ECG and avoid adding true CYP3A4 inhibitors.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Ethinyl estradiol-drospirenone
- Ethinyl estradiol-drospirenone + Fezolinetant Contraindicated
- Ethinyl estradiol-drospirenone + Ombitasvir / paritaprevir / ritonavir Contraindicated
- Ethinyl estradiol-drospirenone + Ombitasvir / paritaprevir / ritonavir and dasabuvir Contraindicated
- Ethinyl estradiol-drospirenone + Tranexamic acid Contraindicated
- Aminocaproic acid + Ethinyl estradiol-drospirenone Major
- Amobarbital + Ethinyl estradiol-drospirenone Major
Other interactions of Cisapride
- Apomorphine + Cisapride Contraindicated
- Artemether + Cisapride Contraindicated
- Azithromycin + Cisapride Contraindicated
- Ceritinib + Cisapride Contraindicated
- Chloroquine + Cisapride Contraindicated
- Cisapride + Citalopram Contraindicated
Frequently asked questions
Can I take Cisapride with Ethinyl estradiol-drospirenone?
MediHelp rates the interaction as minor. Cisapride and Ethinyl estradiol-drospirenone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Cisapride is a sensitive CYP3A4 substrate with QT-prolongation risk, so any rise in levels is of concern. Drospirenone is not an established CYP3A4 inhibitor, so the practical risk from this contraceptive is likely low, but cisapride use is heavily restricted.
How serious is the interaction between Cisapride and Ethinyl estradiol-drospirenone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Cisapride is available only under restricted access; if used, check the ECG and avoid adding true CYP3A4 inhibitors.
What other medicines interact with Ethinyl estradiol-drospirenone?
MediHelp also lists interactions of Ethinyl estradiol-drospirenone with, for example, Fezolinetant, Ombitasvir / paritaprevir / ritonavir, Ombitasvir / paritaprevir / ritonavir and dasabuvir. The full list is on the Ethinyl estradiol-drospirenone page.
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