Drug interactions
Clarithromycin + Doravirine
Severity: Minor
Clarithromycin and Doravirine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Clarithromycin raises doravirine exposure. Doravirine is generally well tolerated, so the increase is unlikely to be clinically important for most patients.
What this interaction means in plain words
Clarithromycin and Doravirine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Clarithromycin belongs to Anti Bacterial; Doravirine belongs to Anti Virals.
Why it happens
Clarithromycin inhibits CYP3A4, the main route of doravirine metabolism.
What to do
No dose adjustment is required. Monitor for adverse effects such as nausea, headache and sleep disturbance.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Clarithromycin
- Astemizole + Clarithromycin Contraindicated
- Avanafil + Clarithromycin Contraindicated
- Cisapride + Clarithromycin Contraindicated
- Clarithromycin + Colchicine Contraindicated
- Clarithromycin + Conivaptan Contraindicated
- Clarithromycin + Dihydroergotamine Contraindicated
Other interactions of Doravirine
- Amobarbital + Doravirine Contraindicated
- Apalutamide + Doravirine Contraindicated
- Carbamazepine + Doravirine Contraindicated
- Doravirine + Efavirenz Contraindicated
- Doravirine + Enzalutamide Contraindicated
- Doravirine + Mitotane Contraindicated
Frequently asked questions
Can I take Clarithromycin with Doravirine?
MediHelp rates the interaction as minor. Clarithromycin and Doravirine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Clarithromycin raises doravirine exposure. Doravirine is generally well tolerated, so the increase is unlikely to be clinically important for most patients.
How serious is the interaction between Clarithromycin and Doravirine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is required. Monitor for adverse effects such as nausea, headache and sleep disturbance.
What other medicines interact with Clarithromycin?
MediHelp also lists interactions of Clarithromycin with, for example, Astemizole, Avanafil, Cisapride. The full list is on the Clarithromycin page.
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