Drug interactions
Clarithromycin + Enzalutamide
Severity: Moderate
Clarithromycin and Enzalutamide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Strong CYP3A4 inhibitors can raise enzalutamide exposure, but enzalutamide is also a strong CYP3A4 inducer that may lower clarithromycin levels. The net effect is limited and is mainly relevant for adverse effects such as seizures.
What this interaction means in plain words
Clarithromycin and Enzalutamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Clarithromycin belongs to Anti Bacterial; Enzalutamide belongs to Endocrine.
Why it happens
CYP3A4 and CYP2C8 inhibition may increase enzalutamide exposure, while enzalutamide induces clarithromycin metabolism.
What to do
Avoid strong CYP3A4 inhibitors where possible; if used, monitor for enzalutamide toxicity and consider reducing its dose.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Clarithromycin
- Astemizole + Clarithromycin Contraindicated
- Avanafil + Clarithromycin Contraindicated
- Cisapride + Clarithromycin Contraindicated
- Clarithromycin + Colchicine Contraindicated
- Clarithromycin + Conivaptan Contraindicated
- Clarithromycin + Dihydroergotamine Contraindicated
Other interactions of Enzalutamide
- Doravirine + Enzalutamide Contraindicated
- Elbasvir / grazoprevir + Enzalutamide Contraindicated
- Ensitrelvir + Enzalutamide Contraindicated
- Enzalutamide + Fostemsavir Contraindicated
- Enzalutamide + Isavuconazonium Contraindicated
- Enzalutamide + Lenacapavir Contraindicated
Frequently asked questions
Can I take Clarithromycin with Enzalutamide?
MediHelp rates the interaction as moderate. Clarithromycin and Enzalutamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Strong CYP3A4 inhibitors can raise enzalutamide exposure, but enzalutamide is also a strong CYP3A4 inducer that may lower clarithromycin levels. The net effect is limited and is mainly relevant for adverse effects such as seizures.
How serious is the interaction between Clarithromycin and Enzalutamide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid strong CYP3A4 inhibitors where possible; if used, monitor for enzalutamide toxicity and consider reducing its dose.
What other medicines interact with Clarithromycin?
MediHelp also lists interactions of Clarithromycin with, for example, Astemizole, Avanafil, Cisapride. The full list is on the Clarithromycin page.
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