Drug interactions
Clarithromycin + Ivermectin
Severity: Minor
Clarithromycin and Ivermectin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Clarithromycin may increase ivermectin concentrations by reducing its efflux. Higher exposure could increase adverse effects such as dizziness, gastrointestinal upset or neurotoxicity, though the clinical effect is generally modest.
What this interaction means in plain words
Clarithromycin and Ivermectin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Clarithromycin belongs to Anti Bacterial; Ivermectin belongs to Anti Parasitic.
Why it happens
Inhibition of P-glycoprotein-mediated efflux of ivermectin, with possible minor CYP3A4 contribution.
What to do
No dose change is normally needed for short ivermectin courses. Monitor for increased adverse effects such as dizziness or neurological symptoms.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Clarithromycin
- Astemizole + Clarithromycin Contraindicated
- Avanafil + Clarithromycin Contraindicated
- Cisapride + Clarithromycin Contraindicated
- Clarithromycin + Colchicine Contraindicated
- Clarithromycin + Conivaptan Contraindicated
- Clarithromycin + Dihydroergotamine Contraindicated
Other interactions of Ivermectin
- Erdafitinib + Ivermectin Moderate
- Ivermectin + Lasmiditan Moderate
- Ivermectin + Quinidine Moderate
- Ivermectin + Rifampin Moderate
- Ivermectin + Sotorasib Moderate
- Ivermectin + Tepotinib Moderate
Frequently asked questions
Can I take Clarithromycin with Ivermectin?
MediHelp rates the interaction as minor. Clarithromycin and Ivermectin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Clarithromycin may increase ivermectin concentrations by reducing its efflux. Higher exposure could increase adverse effects such as dizziness, gastrointestinal upset or neurotoxicity, though the clinical effect is generally modest.
How serious is the interaction between Clarithromycin and Ivermectin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is normally needed for short ivermectin courses. Monitor for increased adverse effects such as dizziness or neurological symptoms.
What other medicines interact with Clarithromycin?
MediHelp also lists interactions of Clarithromycin with, for example, Astemizole, Avanafil, Cisapride. The full list is on the Clarithromycin page.
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