Drug interactions
Clarithromycin + Perampanel
Severity: Moderate
Clarithromycin and Perampanel: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Clarithromycin may increase perampanel concentrations, potentially worsening dizziness, somnolence, ataxia and psychiatric effects. Strong CYP3A inhibitors have only a modest effect, but sensitive patients may have problems.
What this interaction means in plain words
Clarithromycin and Perampanel can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Clarithromycin belongs to Anti Bacterial; Perampanel belongs to Central Nervous System.
Why it happens
Clarithromycin inhibits CYP3A4-mediated metabolism of perampanel.
What to do
Monitor for CNS adverse effects such as dizziness, sedation and mood changes. Reduce the perampanel dose if tolerability worsens.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Clarithromycin
- Astemizole + Clarithromycin Contraindicated
- Avanafil + Clarithromycin Contraindicated
- Cisapride + Clarithromycin Contraindicated
- Clarithromycin + Colchicine Contraindicated
- Clarithromycin + Conivaptan Contraindicated
- Clarithromycin + Dihydroergotamine Contraindicated
Other interactions of Perampanel
- Apalutamide + Perampanel Major
- Enzalutamide + Perampanel Major
- Alprazolam + Perampanel Moderate
- Amisulpride + Perampanel Moderate
- Amobarbital + Perampanel Moderate
- Asenapine + Perampanel Moderate
Frequently asked questions
Can I take Clarithromycin with Perampanel?
MediHelp rates the interaction as moderate. Clarithromycin and Perampanel can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Clarithromycin may increase perampanel concentrations, potentially worsening dizziness, somnolence, ataxia and psychiatric effects. Strong CYP3A inhibitors have only a modest effect, but sensitive patients may have problems.
How serious is the interaction between Clarithromycin and Perampanel?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for CNS adverse effects such as dizziness, sedation and mood changes. Reduce the perampanel dose if tolerability worsens.
What other medicines interact with Clarithromycin?
MediHelp also lists interactions of Clarithromycin with, for example, Astemizole, Avanafil, Cisapride. The full list is on the Clarithromycin page.
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