Drug interactions
Clarithromycin + Progesterone
Severity: Minor
Clarithromycin and Progesterone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Clarithromycin may increase progesterone concentrations. This could increase progestogenic adverse effects such as sedation, dizziness, and mood changes, although the effect is usually short-lived and tolerable.
What this interaction means in plain words
Clarithromycin and Progesterone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Clarithromycin belongs to Anti Bacterial; Progesterone belongs to Endocrine.
Why it happens
Clarithromycin inhibits CYP3A4, reducing progesterone metabolism.
What to do
No routine change is needed during a short antibiotic course. Monitor for excess sedation or dizziness and reduce the progesterone dose if they occur.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Progesterone
Other interactions of Clarithromycin
- Astemizole + Clarithromycin Contraindicated
- Avanafil + Clarithromycin Contraindicated
- Cisapride + Clarithromycin Contraindicated
- Clarithromycin + Colchicine Contraindicated
- Clarithromycin + Conivaptan Contraindicated
- Clarithromycin + Dihydroergotamine Contraindicated
Frequently asked questions
Can I take Clarithromycin with Progesterone?
MediHelp rates the interaction as minor. Clarithromycin and Progesterone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Clarithromycin may increase progesterone concentrations. This could increase progestogenic adverse effects such as sedation, dizziness, and mood changes, although the effect is usually short-lived and tolerable.
How serious is the interaction between Clarithromycin and Progesterone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine change is needed during a short antibiotic course. Monitor for excess sedation or dizziness and reduce the progesterone dose if they occur.
What other medicines interact with Progesterone?
MediHelp also lists interactions of Progesterone with, for example, Apalutamide, Carbamazepine, Enzalutamide. The full list is on the Progesterone page.
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