Drug interactions
Clobazam + Prochlorperazine
Severity: Moderate
Clobazam and Prochlorperazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs depress the central nervous system, so using them together can cause deeper sedation, impaired psychomotor performance and respiratory depression. Elderly or debilitated patients and those with respiratory disease are at higher risk.
What this interaction means in plain words
Clobazam and Prochlorperazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Clobazam belongs to Central Nervous System; Prochlorperazine belongs to Central Nervous System.
Why it happens
Additive CNS depression through GABA-A potentiation by clobazam and dopamine/histamine/adrenergic blockade by prochlorperazine.
What to do
Start with the lowest effective doses and monitor sedation and respiratory status, especially after dose increases. Advise patients to avoid driving and other hazardous tasks until their response is known.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Prochlorperazine
- Dronedarone + Prochlorperazine Contraindicated
- Ibutilide + Prochlorperazine Contraindicated
- Nilotinib + Prochlorperazine Contraindicated
- Pimozide + Prochlorperazine Contraindicated
- Prochlorperazine + Thioridazine Contraindicated
- Amiodarone + Prochlorperazine Major
Other interactions of Clobazam
- Amobarbital + Clobazam Major
- Buprenorphine + Clobazam Major
- Butorphanol + Clobazam Major
- Carisoprodol + Clobazam Major
- Chloral hydrate + Clobazam Major
- Clobazam + Clozapine Major
Frequently asked questions
Can I take Clobazam with Prochlorperazine?
MediHelp rates the interaction as moderate. Clobazam and Prochlorperazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs depress the central nervous system, so using them together can cause deeper sedation, impaired psychomotor performance and respiratory depression. Elderly or debilitated patients and those with respiratory disease are at higher risk.
How serious is the interaction between Clobazam and Prochlorperazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Start with the lowest effective doses and monitor sedation and respiratory status, especially after dose increases. Advise patients to avoid driving and other hazardous tasks until their response is known.
What other medicines interact with Prochlorperazine?
MediHelp also lists interactions of Prochlorperazine with, for example, Dronedarone, Ibutilide, Nilotinib. The full list is on the Prochlorperazine page.
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