Drug interactions
Clobazam + Ticlopidine
Severity: Moderate
Clobazam and Ticlopidine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ticlopidine inhibits CYP2C19, which converts the active metabolite N-desmethylclobazam to inactive products. Exposure to this metabolite can rise, increasing sedation, drowsiness and other CNS effects.
What this interaction means in plain words
Clobazam and Ticlopidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Clobazam belongs to Central Nervous System; Ticlopidine belongs to Cardiovascular.
Why it happens
Ticlopidine inhibits CYP2C19, reducing clearance of N-desmethylclobazam.
What to do
Monitor for sedation and consider reducing the clobazam dose; adjust based on clinical response.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ticlopidine
Other interactions of Clobazam
- Amobarbital + Clobazam Major
- Buprenorphine + Clobazam Major
- Butorphanol + Clobazam Major
- Carisoprodol + Clobazam Major
- Chloral hydrate + Clobazam Major
- Clobazam + Clozapine Major
Frequently asked questions
Can I take Clobazam with Ticlopidine?
MediHelp rates the interaction as moderate. Clobazam and Ticlopidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ticlopidine inhibits CYP2C19, which converts the active metabolite N-desmethylclobazam to inactive products. Exposure to this metabolite can rise, increasing sedation, drowsiness and other CNS effects.
How serious is the interaction between Clobazam and Ticlopidine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for sedation and consider reducing the clobazam dose; adjust based on clinical response.
What other medicines interact with Ticlopidine?
MediHelp also lists interactions of Ticlopidine with, for example, Mavacamten, Abrocitinib, Acetylsalicylic acid. The full list is on the Ticlopidine page.
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