Drug interactions
Clomipramine + Elagolix
Severity: Minor
Clomipramine and Elagolix: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Elagolix is a weak CYP2C19 inhibitor and may modestly raise clomipramine exposure. Any increase is expected to be small, but could increase anticholinergic and sedative adverse effects.
What this interaction means in plain words
Clomipramine and Elagolix have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Clomipramine belongs to Central Nervous System; Elagolix belongs to Musculoskeletal.
Why it happens
Weak inhibition of CYP2C19-mediated clomipramine demethylation by elagolix.
What to do
No routine dose change is required; monitor for tricyclic adverse effects when elagolix is started. Lower the clomipramine dose if toxicity appears.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Clomipramine
- Arsenic trioxide + Clomipramine Contraindicated
- Clomipramine + Dofetilide Contraindicated
- Clomipramine + Droperidol Contraindicated
- Clomipramine + Isocarboxazid Contraindicated
- Clomipramine + Methylene blue Contraindicated
- Clomipramine + Pentamidine Contraindicated
Other interactions of Elagolix
- Cyclosporin + Elagolix Contraindicated
- Elagolix + Gemfibrozil Contraindicated
- Desogestrel-ethinyl estradiol + Elagolix Major
- Elagolix + Erythromycin Major
- Elagolix + Ethinyl estradiol-drospirenone Major
- Elagolix + Ethinyl estradiol-levonorgestrel Major
Frequently asked questions
Can I take Clomipramine with Elagolix?
MediHelp rates the interaction as minor. Clomipramine and Elagolix have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Elagolix is a weak CYP2C19 inhibitor and may modestly raise clomipramine exposure. Any increase is expected to be small, but could increase anticholinergic and sedative adverse effects.
How serious is the interaction between Clomipramine and Elagolix?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine dose change is required; monitor for tricyclic adverse effects when elagolix is started. Lower the clomipramine dose if toxicity appears.
What other medicines interact with Clomipramine?
MediHelp also lists interactions of Clomipramine with, for example, Arsenic trioxide, Dofetilide, Droperidol. The full list is on the Clomipramine page.
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