Drug interactions
Clomipramine + Lisdexamfetamine
Severity: Major
Clomipramine and Lisdexamfetamine: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tricyclics can potentiate amphetamine effects by raising amphetamine levels and increasing adrenergic activity, causing hypertension, tachycardia, arrhythmia and agitation. Serotonin syndrome and lowered seizure threshold are additional concerns.
What this interaction means in plain words
Clomipramine and Lisdexamfetamine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Clomipramine belongs to Central Nervous System; Lisdexamfetamine belongs to Central Nervous System.
Why it happens
Clomipramine blocks norepinephrine reuptake and inhibits CYP2D6-mediated amphetamine metabolism, adding to amphetamine-induced monoamine release.
What to do
Avoid combining where possible; if both are required, use low doses, monitor blood pressure, heart rate and mental status, and adjust the lisdexamfetamine dose.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Clomipramine and Lisdexamfetamine, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
References
Other interactions of Clomipramine
- Arsenic trioxide + Clomipramine Contraindicated
- Clomipramine + Dofetilide Contraindicated
- Clomipramine + Droperidol Contraindicated
- Clomipramine + Isocarboxazid Contraindicated
- Clomipramine + Methylene blue Contraindicated
- Clomipramine + Pentamidine Contraindicated
Other interactions of Lisdexamfetamine
- Isocarboxazid + Lisdexamfetamine Contraindicated
- Linezolid + Lisdexamfetamine Contraindicated
- Lisdexamfetamine + Phenelzine Contraindicated
- Lisdexamfetamine + Procarbazine Contraindicated
- Lisdexamfetamine + Rasagiline Contraindicated
- Lisdexamfetamine + Safinamide Contraindicated
Frequently asked questions
Can I take Clomipramine with Lisdexamfetamine?
MediHelp rates the interaction as major. Clomipramine and Lisdexamfetamine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Tricyclics can potentiate amphetamine effects by raising amphetamine levels and increasing adrenergic activity, causing hypertension, tachycardia, arrhythmia and agitation. Serotonin syndrome and lowered seizure threshold are additional concerns.
How serious is the interaction between Clomipramine and Lisdexamfetamine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combining where possible; if both are required, use low doses, monitor blood pressure, heart rate and mental status, and adjust the lisdexamfetamine dose.
What other medicines interact with Clomipramine?
MediHelp also lists interactions of Clomipramine with, for example, Arsenic trioxide, Dofetilide, Droperidol. The full list is on the Clomipramine page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
