Drug interactions
Clomipramine + Maraviroc
Severity: Minor
Clomipramine and Maraviroc: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Maraviroc has been listed as raising CYP2D6 substrate levels, but it is not a clinically meaningful CYP2D6 inhibitor in vivo. A real effect on clomipramine exposure is unlikely.
What this interaction means in plain words
Clomipramine and Maraviroc have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Clomipramine belongs to Central Nervous System; Maraviroc belongs to Anti Virals.
Why it happens
Possible weak CYP2D6 inhibition by maraviroc; not established clinically.
What to do
No dose change is needed. Monitor for tricyclic adverse effects if symptoms arise.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Clomipramine
- Arsenic trioxide + Clomipramine Contraindicated
- Clomipramine + Dofetilide Contraindicated
- Clomipramine + Droperidol Contraindicated
- Clomipramine + Isocarboxazid Contraindicated
- Clomipramine + Methylene blue Contraindicated
- Clomipramine + Pentamidine Contraindicated
Other interactions of Maraviroc
- Amobarbital + Maraviroc Major
- Apalutamide + Maraviroc Major
- Carbamazepine + Maraviroc Major
- Clarithromycin + Maraviroc Major
- Efavirenz + Maraviroc Major
- Enzalutamide + Maraviroc Major
Frequently asked questions
Can I take Clomipramine with Maraviroc?
MediHelp rates the interaction as minor. Clomipramine and Maraviroc have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Maraviroc has been listed as raising CYP2D6 substrate levels, but it is not a clinically meaningful CYP2D6 inhibitor in vivo. A real effect on clomipramine exposure is unlikely.
How serious is the interaction between Clomipramine and Maraviroc?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is needed. Monitor for tricyclic adverse effects if symptoms arise.
What other medicines interact with Clomipramine?
MediHelp also lists interactions of Clomipramine with, for example, Arsenic trioxide, Dofetilide, Droperidol. The full list is on the Clomipramine page.
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