Drug interactions
Clomipramine + Prochlorperazine
Severity: Major
Clomipramine and Prochlorperazine: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can prolong the QT interval and cause sedation, anticholinergic effects and hypotension. Clomipramine is a CYP2D6 substrate and phenothiazines may raise tricyclic concentrations, further increasing the risk of arrhythmia and seizures.
What this interaction means in plain words
Clomipramine and Prochlorperazine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Clomipramine belongs to Central Nervous System; Prochlorperazine belongs to Central Nervous System.
Why it happens
Additive QT prolongation and CNS depression, with possible pharmacokinetic inhibition of tricyclic metabolism by the phenothiazine.
What to do
Obtain a baseline ECG and monitor it, and correct electrolyte abnormalities. Consider tricyclic dose reduction or an alternative antiemetic.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Prochlorperazine
- Dronedarone + Prochlorperazine Contraindicated
- Ibutilide + Prochlorperazine Contraindicated
- Nilotinib + Prochlorperazine Contraindicated
- Pimozide + Prochlorperazine Contraindicated
- Prochlorperazine + Thioridazine Contraindicated
- Amiodarone + Prochlorperazine Major
Other interactions of Clomipramine
- Arsenic trioxide + Clomipramine Contraindicated
- Clomipramine + Dofetilide Contraindicated
- Clomipramine + Droperidol Contraindicated
- Clomipramine + Isocarboxazid Contraindicated
- Clomipramine + Methylene blue Contraindicated
- Clomipramine + Pentamidine Contraindicated
Frequently asked questions
Can I take Clomipramine with Prochlorperazine?
MediHelp rates the interaction as major. Clomipramine and Prochlorperazine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both drugs can prolong the QT interval and cause sedation, anticholinergic effects and hypotension. Clomipramine is a CYP2D6 substrate and phenothiazines may raise tricyclic concentrations, further increasing the risk of arrhythmia and seizures.
How serious is the interaction between Clomipramine and Prochlorperazine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG and monitor it, and correct electrolyte abnormalities. Consider tricyclic dose reduction or an alternative antiemetic.
What other medicines interact with Prochlorperazine?
MediHelp also lists interactions of Prochlorperazine with, for example, Dronedarone, Ibutilide, Nilotinib. The full list is on the Prochlorperazine page.
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