Drug interactions
Clomipramine + Vilazodone
Severity: Major
Clomipramine and Vilazodone: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs enhance serotonergic neurotransmission, so the combination can cause serotonin syndrome with agitation, hyperthermia, clonus and autonomic instability. Vilazodone labeling warns about concomitant serotonergic drugs.
What this interaction means in plain words
Clomipramine and Vilazodone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Clomipramine belongs to Central Nervous System; Vilazodone belongs to Central Nervous System.
Why it happens
Additive serotonin reuptake inhibition, with vilazodone partial 5-HT1A agonism.
What to do
Avoid if possible; if used, start low and monitor for serotonin syndrome, and stop both drugs and give supportive care if it develops.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Clomipramine
- Arsenic trioxide + Clomipramine Contraindicated
- Clomipramine + Dofetilide Contraindicated
- Clomipramine + Droperidol Contraindicated
- Clomipramine + Isocarboxazid Contraindicated
- Clomipramine + Methylene blue Contraindicated
- Clomipramine + Pentamidine Contraindicated
Other interactions of Vilazodone
- Isocarboxazid + Vilazodone Contraindicated
- Methylene blue + Vilazodone Contraindicated
- Phenelzine + Vilazodone Contraindicated
- Rasagiline + Vilazodone Contraindicated
- Selegiline transdermal + Vilazodone Contraindicated
- Selegiline + Vilazodone Contraindicated
Frequently asked questions
Can I take Clomipramine with Vilazodone?
MediHelp rates the interaction as major. Clomipramine and Vilazodone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both drugs enhance serotonergic neurotransmission, so the combination can cause serotonin syndrome with agitation, hyperthermia, clonus and autonomic instability. Vilazodone labeling warns about concomitant serotonergic drugs.
How serious is the interaction between Clomipramine and Vilazodone?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid if possible; if used, start low and monitor for serotonin syndrome, and stop both drugs and give supportive care if it develops.
What other medicines interact with Clomipramine?
MediHelp also lists interactions of Clomipramine with, for example, Arsenic trioxide, Dofetilide, Droperidol. The full list is on the Clomipramine page.
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