Drug interactions
Clopidogrel + Felbamate
Severity: Moderate
Clopidogrel and Felbamate: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Felbamate inhibits CYP2C19, which is needed to activate clopidogrel, so platelet inhibition may be reduced. This could lessen protection against stent thrombosis or recurrent ischemic events.
What this interaction means in plain words
Clopidogrel and Felbamate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Clopidogrel belongs to Cardiovascular; Felbamate belongs to Central Nervous System.
Why it happens
CYP2C19 inhibition by felbamate reduces generation of clopidogrel's active metabolite.
What to do
Avoid the combination if possible and consider an alternative P2Y12 inhibitor such as ticagrelor or prasugrel. If both are needed, monitor for ischemic events.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Clopidogrel
Other interactions of Felbamate
- Felbamate + Ulipristal Major
- Amisulpride + Felbamate Moderate
- Amitriptyline + Felbamate Moderate
- Apalutamide + Felbamate Moderate
- Asenapine + Felbamate Moderate
- Bosentan + Felbamate Moderate
Frequently asked questions
Can I take Clopidogrel with Felbamate?
MediHelp rates the interaction as moderate. Clopidogrel and Felbamate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Felbamate inhibits CYP2C19, which is needed to activate clopidogrel, so platelet inhibition may be reduced. This could lessen protection against stent thrombosis or recurrent ischemic events.
How serious is the interaction between Clopidogrel and Felbamate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination if possible and consider an alternative P2Y12 inhibitor such as ticagrelor or prasugrel. If both are needed, monitor for ischemic events.
What other medicines interact with Clopidogrel?
MediHelp also lists interactions of Clopidogrel with, for example, Ombitasvir / paritaprevir / ritonavir and dasabuvir, Abrocitinib, Acetylsalicylic acid. The full list is on the Clopidogrel page.
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