Drug interactions
Clopidogrel + Porfimer
Severity: Moderate
Clopidogrel and Porfimer: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Porfimer sodium photodynamic therapy depends on photoactivation and subsequent vascular and tissue damage. Antiplatelet agents such as clopidogrel may inhibit thromboxane-mediated vascular effects and are listed as agents that may reduce the effect of photodynamic therapy.
What this interaction means in plain words
Clopidogrel and Porfimer can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Clopidogrel belongs to Cardiovascular; Porfimer belongs to Miscellaneous.
Why it happens
Antiplatelet inhibition of platelet-mediated vascular responses that contribute to porfimer-induced tumor necrosis.
What to do
If feasible, assess whether clopidogrel can be interrupted around photodynamic therapy, weighing thrombotic risk. Monitor treatment response.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Clopidogrel
Other interactions of Porfimer
Frequently asked questions
Can I take Clopidogrel with Porfimer?
MediHelp rates the interaction as moderate. Clopidogrel and Porfimer can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Porfimer sodium photodynamic therapy depends on photoactivation and subsequent vascular and tissue damage. Antiplatelet agents such as clopidogrel may inhibit thromboxane-mediated vascular effects and are listed as agents that may reduce the effect of photodynamic therapy.
How serious is the interaction between Clopidogrel and Porfimer?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: If feasible, assess whether clopidogrel can be interrupted around photodynamic therapy, weighing thrombotic risk. Monitor treatment response.
What other medicines interact with Clopidogrel?
MediHelp also lists interactions of Clopidogrel with, for example, Ombitasvir / paritaprevir / ritonavir and dasabuvir, Abrocitinib, Acetylsalicylic acid. The full list is on the Clopidogrel page.
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