Drug interactions
Clorazepate + Perampanel
Severity: Moderate
Clorazepate and Perampanel: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Perampanel causes dose-related somnolence, dizziness and impaired coordination, and these can be additive with benzodiazepines. Perampanel can also cause hostility and mood changes, which may need attention in patients on sedatives.
What this interaction means in plain words
Clorazepate and Perampanel can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Clorazepate belongs to Central Nervous System; Perampanel belongs to Central Nervous System.
Why it happens
Additive CNS depression through AMPA receptor antagonism and GABA-A potentiation.
What to do
Titrate perampanel slowly and monitor for somnolence, ataxia and mood or behavioral changes. Advise patients against driving until the combined effect is known.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Clorazepate
- Calcium / magnesium / potassium / sodium oxybates + Clorazepate Contraindicated
- Clorazepate + Sodium oxybate Contraindicated
- Alfentanil + Clorazepate Major
- Alprazolam + Clorazepate Major
- Amobarbital + Clorazepate Major
- Belladonna and opium + Clorazepate Major
Other interactions of Perampanel
- Apalutamide + Perampanel Major
- Enzalutamide + Perampanel Major
- Alprazolam + Perampanel Moderate
- Amisulpride + Perampanel Moderate
- Amobarbital + Perampanel Moderate
- Asenapine + Perampanel Moderate
Frequently asked questions
Can I take Clorazepate with Perampanel?
MediHelp rates the interaction as moderate. Clorazepate and Perampanel can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Perampanel causes dose-related somnolence, dizziness and impaired coordination, and these can be additive with benzodiazepines. Perampanel can also cause hostility and mood changes, which may need attention in patients on sedatives.
How serious is the interaction between Clorazepate and Perampanel?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Titrate perampanel slowly and monitor for somnolence, ataxia and mood or behavioral changes. Advise patients against driving until the combined effect is known.
What other medicines interact with Clorazepate?
MediHelp also lists interactions of Clorazepate with, for example, Calcium / magnesium / potassium / sodium oxybates, Sodium oxybate, Alfentanil. The full list is on the Clorazepate page.
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