Drug interactions
Clorazepate + Posaconazole
Severity: Moderate
Clorazepate and Posaconazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Clorazepate is converted to the active metabolite nordazepam, which is further metabolized partly by CYP3A4. Posaconazole may raise exposure to the active benzodiazepine species, increasing sedation, psychomotor impairment and respiratory depression.
What this interaction means in plain words
Clorazepate and Posaconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Clorazepate belongs to Central Nervous System; Posaconazole belongs to Anti Fungals.
Why it happens
Posaconazole inhibits CYP3A4-mediated metabolism of clorazepate's active metabolite.
What to do
Monitor for excessive sedation and reduce the clorazepate dose if needed. Warn patients about driving and other hazardous tasks.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Posaconazole
- Artemether + Posaconazole Contraindicated
- Avanafil + Posaconazole Contraindicated
- Cobimetinib + Posaconazole Contraindicated
- Conivaptan + Posaconazole Contraindicated
- Dihydroergotamine intranasal + Posaconazole Contraindicated
- Dihydroergotamine + Posaconazole Contraindicated
Other interactions of Clorazepate
- Calcium / magnesium / potassium / sodium oxybates + Clorazepate Contraindicated
- Clorazepate + Sodium oxybate Contraindicated
- Alfentanil + Clorazepate Major
- Alprazolam + Clorazepate Major
- Amobarbital + Clorazepate Major
- Belladonna and opium + Clorazepate Major
Frequently asked questions
Can I take Clorazepate with Posaconazole?
MediHelp rates the interaction as moderate. Clorazepate and Posaconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Clorazepate is converted to the active metabolite nordazepam, which is further metabolized partly by CYP3A4. Posaconazole may raise exposure to the active benzodiazepine species, increasing sedation, psychomotor impairment and respiratory depression.
How serious is the interaction between Clorazepate and Posaconazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for excessive sedation and reduce the clorazepate dose if needed. Warn patients about driving and other hazardous tasks.
What other medicines interact with Posaconazole?
MediHelp also lists interactions of Posaconazole with, for example, Artemether, Avanafil, Cobimetinib. The full list is on the Posaconazole page.
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