Drug interactions
Clorazepate + Propofol
Severity: Major
Clorazepate and Propofol: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Propofol with a benzodiazepine produces additive sedation, hypotension and respiratory depression. A patient who takes clorazepate regularly may need a lower propofol dose, and recovery may be delayed.
What this interaction means in plain words
Clorazepate and Propofol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Clorazepate belongs to Central Nervous System; Propofol belongs to Central Nervous System.
Why it happens
Additive GABA-A receptor potentiation causing synergistic CNS and respiratory depression.
What to do
Reduce and titrate propofol carefully, with continuous monitoring of oxygen saturation, ventilation and blood pressure. Ensure airway management capability is available.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Clorazepate
- Calcium / magnesium / potassium / sodium oxybates + Clorazepate Contraindicated
- Clorazepate + Sodium oxybate Contraindicated
- Alfentanil + Clorazepate Major
- Alprazolam + Clorazepate Major
- Amobarbital + Clorazepate Major
- Belladonna and opium + Clorazepate Major
Other interactions of Propofol
Frequently asked questions
Can I take Clorazepate with Propofol?
MediHelp rates the interaction as major. Clorazepate and Propofol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Propofol with a benzodiazepine produces additive sedation, hypotension and respiratory depression. A patient who takes clorazepate regularly may need a lower propofol dose, and recovery may be delayed.
How serious is the interaction between Clorazepate and Propofol?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Reduce and titrate propofol carefully, with continuous monitoring of oxygen saturation, ventilation and blood pressure. Ensure airway management capability is available.
What other medicines interact with Clorazepate?
MediHelp also lists interactions of Clorazepate with, for example, Calcium / magnesium / potassium / sodium oxybates, Sodium oxybate, Alfentanil. The full list is on the Clorazepate page.
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