Drug interactions
Clorazepate + Tucatinib
Severity: Moderate
Clorazepate and Tucatinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tucatinib inhibits CYP3A4 and can raise exposure to drugs cleared by this pathway. Clorazepate is converted to the active metabolite nordiazepam, which is cleared partly by CYP3A4, so levels may rise and cause excess sedation, psychomotor impairment and respiratory depression.
What this interaction means in plain words
Clorazepate and Tucatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Clorazepate belongs to Central Nervous System; Tucatinib belongs to Oncology.
Why it happens
Tucatinib inhibits CYP3A4, reducing the metabolic clearance of nordiazepam, the active metabolite of clorazepate.
What to do
Monitor for excessive sedation and reduce the clorazepate dose if signs of over-sedation appear. Consider an alternative benzodiazepine not dependent on CYP3A4, such as lorazepam, if the combination is needed long term.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Clorazepate
- Calcium / magnesium / potassium / sodium oxybates + Clorazepate Contraindicated
- Clorazepate + Sodium oxybate Contraindicated
- Alfentanil + Clorazepate Major
- Alprazolam + Clorazepate Major
- Amobarbital + Clorazepate Major
- Belladonna and opium + Clorazepate Major
Other interactions of Tucatinib
- Cisapride + Tucatinib Contraindicated
- Eletriptan + Tucatinib Contraindicated
- Ergotamine + Tucatinib Contraindicated
- Flibanserin + Tucatinib Contraindicated
- Ranolazine + Tucatinib Contraindicated
- Amobarbital + Tucatinib Major
Frequently asked questions
Can I take Clorazepate with Tucatinib?
MediHelp rates the interaction as moderate. Clorazepate and Tucatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Tucatinib inhibits CYP3A4 and can raise exposure to drugs cleared by this pathway. Clorazepate is converted to the active metabolite nordiazepam, which is cleared partly by CYP3A4, so levels may rise and cause excess sedation, psychomotor impairment and respiratory depression.
How serious is the interaction between Clorazepate and Tucatinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for excessive sedation and reduce the clorazepate dose if signs of over-sedation appear. Consider an alternative benzodiazepine not dependent on CYP3A4, such as lorazepam, if the combination is needed long term.
What other medicines interact with Clorazepate?
MediHelp also lists interactions of Clorazepate with, for example, Calcium / magnesium / potassium / sodium oxybates, Sodium oxybate, Alfentanil. The full list is on the Clorazepate page.
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