Drug interactions
Colchicine + Digoxin
Severity: Moderate
Colchicine and Digoxin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs are P-glycoprotein substrates and each has been reported to cause myopathy. Combined use may raise digoxin or colchicine exposure and lead to toxicity, particularly in renal impairment.
What this interaction means in plain words
Colchicine and Digoxin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Colchicine belongs to Genitourinary; Digoxin belongs to Cardiovascular.
Why it happens
Possible competition for P-glycoprotein efflux, with additive neuromuscular toxicity.
What to do
Monitor digoxin concentration and signs of toxicity, and watch for muscle symptoms. Reduce colchicine dose in renal impairment.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Colchicine
- Clarithromycin + Colchicine Contraindicated
- Cobicistat + Colchicine Contraindicated
- Colchicine + Cyclosporine Contraindicated
- Colchicine + Ensitrelvir Contraindicated
- Colchicine + Levoketoconazole Contraindicated
- Colchicine + Nirmatrelvir Contraindicated
Other interactions of Digoxin
- Digoxin + Lily of the valley Contraindicated
- Digoxin + Squill Contraindicated
- Adagrasib + Digoxin Major
- Amiodarone + Digoxin Major
- Amlodipine-hydrochlorothiazide-valsartan + Digoxin Major
- Amphotericin b deoxycholate + Digoxin Major
Frequently asked questions
Can I take Colchicine with Digoxin?
MediHelp rates the interaction as moderate. Colchicine and Digoxin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs are P-glycoprotein substrates and each has been reported to cause myopathy. Combined use may raise digoxin or colchicine exposure and lead to toxicity, particularly in renal impairment.
How serious is the interaction between Colchicine and Digoxin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor digoxin concentration and signs of toxicity, and watch for muscle symptoms. Reduce colchicine dose in renal impairment.
What other medicines interact with Colchicine?
MediHelp also lists interactions of Colchicine with, for example, Clarithromycin, Cobicistat, Cyclosporine. The full list is on the Colchicine page.
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