Drug interactions
Colchicine + Fedratinib
Severity: Major
Colchicine and Fedratinib: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fedratinib inhibits CYP3A4 and P-glycoprotein, which may increase colchicine exposure. Higher colchicine levels raise the risk of serious toxicity including gastrointestinal effects, myopathy and bone marrow suppression.
What this interaction means in plain words
Colchicine and Fedratinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Colchicine belongs to Genitourinary; Fedratinib belongs to Oncology.
Why it happens
Fedratinib inhibits CYP3A4 (and P-gp), reducing colchicine clearance.
What to do
Reduce the colchicine dose according to labeling for CYP3A4/P-gp inhibitors and monitor for toxicity. Avoid the combination in patients with renal or hepatic impairment.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Colchicine
- Clarithromycin + Colchicine Contraindicated
- Cobicistat + Colchicine Contraindicated
- Colchicine + Cyclosporine Contraindicated
- Colchicine + Ensitrelvir Contraindicated
- Colchicine + Levoketoconazole Contraindicated
- Colchicine + Nirmatrelvir Contraindicated
Other interactions of Fedratinib
- Fedratinib + Thioridazine Contraindicated
- Amobarbital + Fedratinib Major
- Apalutamide + Fedratinib Major
- Brexpiprazole + Fedratinib Major
- Carbamazepine + Fedratinib Major
- Chloramphenicol + Fedratinib Major
Frequently asked questions
Can I take Colchicine with Fedratinib?
MediHelp rates the interaction as major. Colchicine and Fedratinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Fedratinib inhibits CYP3A4 and P-glycoprotein, which may increase colchicine exposure. Higher colchicine levels raise the risk of serious toxicity including gastrointestinal effects, myopathy and bone marrow suppression.
How serious is the interaction between Colchicine and Fedratinib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Reduce the colchicine dose according to labeling for CYP3A4/P-gp inhibitors and monitor for toxicity. Avoid the combination in patients with renal or hepatic impairment.
What other medicines interact with Colchicine?
MediHelp also lists interactions of Colchicine with, for example, Clarithromycin, Cobicistat, Cyclosporine. The full list is on the Colchicine page.
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