Drug interactions
Colchicine + Nevirapine
Severity: Moderate
Colchicine and Nevirapine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nevirapine induces CYP3A4 and may lower colchicine concentrations, potentially reducing efficacy for gout flares or familial Mediterranean fever. Clinical data are limited, and the effect is usually manageable.
What this interaction means in plain words
Colchicine and Nevirapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Colchicine belongs to Genitourinary; Nevirapine belongs to Anti Virals.
Why it happens
Induction of CYP3A4 by nevirapine increases colchicine metabolism.
What to do
Monitor therapeutic response to colchicine and adjust the dose according to clinical effect. Watch for loss of disease control after nevirapine is started and for colchicine toxicity if nevirapine is stopped.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Colchicine
- Clarithromycin + Colchicine Contraindicated
- Cobicistat + Colchicine Contraindicated
- Colchicine + Cyclosporine Contraindicated
- Colchicine + Ensitrelvir Contraindicated
- Colchicine + Levoketoconazole Contraindicated
- Colchicine + Nirmatrelvir Contraindicated
Other interactions of Nevirapine
- Elbasvir / grazoprevir + Nevirapine Contraindicated
- Nevirapine + Ranolazine Contraindicated
- Nevirapine + St john's wort Contraindicated
- Abemaciclib + Nevirapine Major
- Acalabrutinib + Nevirapine Major
- Amobarbital + Nevirapine Major
Frequently asked questions
Can I take Colchicine with Nevirapine?
MediHelp rates the interaction as moderate. Colchicine and Nevirapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Nevirapine induces CYP3A4 and may lower colchicine concentrations, potentially reducing efficacy for gout flares or familial Mediterranean fever. Clinical data are limited, and the effect is usually manageable.
How serious is the interaction between Colchicine and Nevirapine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor therapeutic response to colchicine and adjust the dose according to clinical effect. Watch for loss of disease control after nevirapine is started and for colchicine toxicity if nevirapine is stopped.
What other medicines interact with Colchicine?
MediHelp also lists interactions of Colchicine with, for example, Clarithromycin, Cobicistat, Cyclosporine. The full list is on the Colchicine page.
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