Drug interactions
Colchicine + Omaveloxolone
Severity: Minor
Colchicine and Omaveloxolone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Omaveloxolone may induce CYP3A4 and lower systemic exposure to colchicine. The clinical significance is likely modest but could diminish colchicine efficacy.
What this interaction means in plain words
Colchicine and Omaveloxolone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Colchicine belongs to Genitourinary; Omaveloxolone belongs to Central Nervous System.
Why it happens
Omaveloxolone weakly induces CYP3A4, increasing colchicine metabolism.
What to do
Monitor colchicine response and adjust the dose if efficacy is inadequate.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Colchicine
- Clarithromycin + Colchicine Contraindicated
- Cobicistat + Colchicine Contraindicated
- Colchicine + Cyclosporine Contraindicated
- Colchicine + Ensitrelvir Contraindicated
- Colchicine + Levoketoconazole Contraindicated
- Colchicine + Nirmatrelvir Contraindicated
Other interactions of Omaveloxolone
Frequently asked questions
Can I take Colchicine with Omaveloxolone?
MediHelp rates the interaction as minor. Colchicine and Omaveloxolone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Omaveloxolone may induce CYP3A4 and lower systemic exposure to colchicine. The clinical significance is likely modest but could diminish colchicine efficacy.
How serious is the interaction between Colchicine and Omaveloxolone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor colchicine response and adjust the dose if efficacy is inadequate.
What other medicines interact with Colchicine?
MediHelp also lists interactions of Colchicine with, for example, Clarithromycin, Cobicistat, Cyclosporine. The full list is on the Colchicine page.
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