Drug interactions
Colchicine + Pravastatin
Severity: Moderate
Colchicine and Pravastatin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can cause myopathy, and combined use may raise the risk of rhabdomyolysis. Risk is higher in older patients and those with renal impairment.
What this interaction means in plain words
Colchicine and Pravastatin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Colchicine belongs to Genitourinary; Pravastatin belongs to Cardiovascular.
Why it happens
Additive myotoxicity.
What to do
Monitor for muscle symptoms and check creatine kinase if they occur. Consider holding the statin during colchicine courses in high-risk patients.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Colchicine
- Clarithromycin + Colchicine Contraindicated
- Cobicistat + Colchicine Contraindicated
- Colchicine + Cyclosporine Contraindicated
- Colchicine + Ensitrelvir Contraindicated
- Colchicine + Levoketoconazole Contraindicated
- Colchicine + Nirmatrelvir Contraindicated
Other interactions of Pravastatin
Frequently asked questions
Can I take Colchicine with Pravastatin?
MediHelp rates the interaction as moderate. Colchicine and Pravastatin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs can cause myopathy, and combined use may raise the risk of rhabdomyolysis. Risk is higher in older patients and those with renal impairment.
How serious is the interaction between Colchicine and Pravastatin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for muscle symptoms and check creatine kinase if they occur. Consider holding the statin during colchicine courses in high-risk patients.
What other medicines interact with Colchicine?
MediHelp also lists interactions of Colchicine with, for example, Clarithromycin, Cobicistat, Cyclosporine. The full list is on the Colchicine page.
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