Drug interactions
Colchicine + Repotrectinib
Severity: Moderate
Colchicine and Repotrectinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Repotrectinib is a CYP3A4 inducer and may reduce colchicine exposure, potentially causing loss of anti-inflammatory efficacy. The effect is predicted from mechanism rather than shown in clinical studies.
What this interaction means in plain words
Colchicine and Repotrectinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Colchicine belongs to Genitourinary; Repotrectinib belongs to Oncology.
Why it happens
CYP3A4 induction by repotrectinib speeds colchicine metabolism.
What to do
Monitor for reduced colchicine response and consider alternative therapy if efficacy is lost.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Colchicine
- Clarithromycin + Colchicine Contraindicated
- Cobicistat + Colchicine Contraindicated
- Colchicine + Cyclosporine Contraindicated
- Colchicine + Ensitrelvir Contraindicated
- Colchicine + Levoketoconazole Contraindicated
- Colchicine + Nirmatrelvir Contraindicated
Other interactions of Repotrectinib
- Apalutamide + Repotrectinib Contraindicated
- Amiodarone + Repotrectinib Major
- Amobarbital + Repotrectinib Major
- Aprepitant + Repotrectinib Major
- Armodafinil + Repotrectinib Major
- Bosentan + Repotrectinib Major
Frequently asked questions
Can I take Colchicine with Repotrectinib?
MediHelp rates the interaction as moderate. Colchicine and Repotrectinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Repotrectinib is a CYP3A4 inducer and may reduce colchicine exposure, potentially causing loss of anti-inflammatory efficacy. The effect is predicted from mechanism rather than shown in clinical studies.
How serious is the interaction between Colchicine and Repotrectinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for reduced colchicine response and consider alternative therapy if efficacy is lost.
What other medicines interact with Colchicine?
MediHelp also lists interactions of Colchicine with, for example, Clarithromycin, Cobicistat, Cyclosporine. The full list is on the Colchicine page.
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