Drug interactions
Colchicine + Siltuximab
Severity: Minor
Colchicine and Siltuximab: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Siltuximab blocks IL-6, which may reverse cytokine-mediated suppression of CYP450 enzymes and increase CYP3A4 activity. This could lower colchicine levels, with the effect most relevant at the start or end of siltuximab therapy.
What this interaction means in plain words
Colchicine and Siltuximab have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Colchicine belongs to Genitourinary; Siltuximab belongs to Miscellaneous.
Why it happens
IL-6 inhibition normalizes suppressed CYP3A4 activity, potentially increasing colchicine metabolism.
What to do
Monitor colchicine response when starting or stopping siltuximab and adjust the dose as needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Colchicine
- Clarithromycin + Colchicine Contraindicated
- Cobicistat + Colchicine Contraindicated
- Colchicine + Cyclosporine Contraindicated
- Colchicine + Ensitrelvir Contraindicated
- Colchicine + Levoketoconazole Contraindicated
- Colchicine + Nirmatrelvir Contraindicated
Other interactions of Siltuximab
- Baricitinib + Siltuximab Major
- Atorvastatin + Siltuximab Moderate
- Carbamazepine + Siltuximab Moderate
- Cyclosporin + Siltuximab Moderate
- Ethinyl estradiol-drospirenone + Siltuximab Moderate
- Ethinyl estradiol-levonorgestrel + Siltuximab Moderate
Frequently asked questions
Can I take Colchicine with Siltuximab?
MediHelp rates the interaction as minor. Colchicine and Siltuximab have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Siltuximab blocks IL-6, which may reverse cytokine-mediated suppression of CYP450 enzymes and increase CYP3A4 activity. This could lower colchicine levels, with the effect most relevant at the start or end of siltuximab therapy.
How serious is the interaction between Colchicine and Siltuximab?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor colchicine response when starting or stopping siltuximab and adjust the dose as needed.
What other medicines interact with Colchicine?
MediHelp also lists interactions of Colchicine with, for example, Clarithromycin, Cobicistat, Cyclosporine. The full list is on the Colchicine page.
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