Drug interactions
Colesevelam + Lomitapide
Severity: Moderate
Colesevelam and Lomitapide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Bile acid sequestrants can bind lomitapide in the gut and reduce its absorption, potentially lowering its LDL-lowering effect. The two are often used together in familial hypercholesterolemia, so timing matters.
What this interaction means in plain words
Colesevelam and Lomitapide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Colesevelam belongs to Endocrine; Lomitapide belongs to Cardiovascular.
Why it happens
Colesevelam binds lomitapide in the gastrointestinal lumen, reducing absorption.
What to do
Separate lomitapide and colesevelam by at least 4 hours and monitor lipid response.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Colesevelam
- Amlodipine-olmesartan-hydrochlorothiazide + Colesevelam Moderate
- Amlodipine-olmesartan + Colesevelam Moderate
- Chenodiol + Colesevelam Moderate
- Cholic acid + Colesevelam Moderate
- Colesevelam + Cyclosporin Moderate
- Colesevelam + Glibenclamide Moderate
Other interactions of Lomitapide
- Aprepitant + Lomitapide Contraindicated
- Clarithromycin + Lomitapide Contraindicated
- Crizotinib + Lomitapide Contraindicated
- Diltiazem + Lomitapide Contraindicated
- Efavirenz + Lomitapide Contraindicated
- Ensitrelvir + Lomitapide Contraindicated
Frequently asked questions
Can I take Colesevelam with Lomitapide?
MediHelp rates the interaction as moderate. Colesevelam and Lomitapide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Bile acid sequestrants can bind lomitapide in the gut and reduce its absorption, potentially lowering its LDL-lowering effect. The two are often used together in familial hypercholesterolemia, so timing matters.
How serious is the interaction between Colesevelam and Lomitapide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Separate lomitapide and colesevelam by at least 4 hours and monitor lipid response.
What other medicines interact with Colesevelam?
MediHelp also lists interactions of Colesevelam with, for example, Amlodipine-olmesartan-hydrochlorothiazide, Amlodipine-olmesartan, Chenodiol. The full list is on the Colesevelam page.
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