Drug interactions
Colesevelam + Omadacycline
Severity: Moderate
Colesevelam and Omadacycline: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Bile acid sequestrants may bind oral tetracyclines and lower their absorption. Reduced omadacycline exposure could compromise antibacterial efficacy.
What this interaction means in plain words
Colesevelam and Omadacycline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Colesevelam belongs to Endocrine; Omadacycline belongs to Anti Bacterial.
Why it happens
Binding of omadacycline in the gut by the resin reduces absorption.
What to do
Separate doses by at least 2 hours, giving omadacycline first, and watch for treatment failure.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Colesevelam
- Amlodipine-olmesartan-hydrochlorothiazide + Colesevelam Moderate
- Amlodipine-olmesartan + Colesevelam Moderate
- Chenodiol + Colesevelam Moderate
- Cholic acid + Colesevelam Moderate
- Colesevelam + Cyclosporin Moderate
- Colesevelam + Glibenclamide Moderate
Other interactions of Omadacycline
- Acitretin + Omadacycline Contraindicated
- Isotretinoin + Omadacycline Major
- Omadacycline + Tretinoin Major
- Aluminum hydroxide + Omadacycline Moderate
- Amoxicillin-clavulanic acid + Omadacycline Moderate
- Amoxicillin + Omadacycline Moderate
Frequently asked questions
Can I take Colesevelam with Omadacycline?
MediHelp rates the interaction as moderate. Colesevelam and Omadacycline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Bile acid sequestrants may bind oral tetracyclines and lower their absorption. Reduced omadacycline exposure could compromise antibacterial efficacy.
How serious is the interaction between Colesevelam and Omadacycline?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Separate doses by at least 2 hours, giving omadacycline first, and watch for treatment failure.
What other medicines interact with Colesevelam?
MediHelp also lists interactions of Colesevelam with, for example, Amlodipine-olmesartan-hydrochlorothiazide, Amlodipine-olmesartan, Chenodiol. The full list is on the Colesevelam page.
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