Drug interactions
Crizotinib + Disopyramide
Severity: Major
Crizotinib and Disopyramide: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Crizotinib can raise disopyramide exposure through CYP3A4 inhibition, and both drugs prolong the QT interval. Together they increase the risk of serious ventricular arrhythmias such as torsades de pointes.
What this interaction means in plain words
Crizotinib and Disopyramide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Crizotinib belongs to Oncology; Disopyramide belongs to Cardiovascular.
Why it happens
Crizotinib inhibits CYP3A4, reducing disopyramide metabolism, and both agents have additive QTc-prolonging effects.
What to do
Avoid the combination where possible and choose an alternative antiarrhythmic. If unavoidable, monitor ECG and electrolytes closely and consider reducing the disopyramide dose.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Crizotinib
- Crizotinib + Flibanserin Contraindicated
- Crizotinib + Lomitapide Contraindicated
- Crizotinib + Lonafarnib Contraindicated
- Crizotinib + Pimozide Contraindicated
- Crizotinib + Saquinavir Contraindicated
- Crizotinib + Thioridazine Contraindicated
Other interactions of Disopyramide
- Amisulpride + Disopyramide Contraindicated
- Desipramine + Disopyramide Contraindicated
- Disopyramide + Dronedarone Contraindicated
- Disopyramide + Itraconazole Contraindicated
- Disopyramide + Ketoconazole Contraindicated
- Disopyramide + Maprotiline Contraindicated
Frequently asked questions
Can I take Crizotinib with Disopyramide?
MediHelp rates the interaction as major. Crizotinib and Disopyramide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Crizotinib can raise disopyramide exposure through CYP3A4 inhibition, and both drugs prolong the QT interval. Together they increase the risk of serious ventricular arrhythmias such as torsades de pointes.
How serious is the interaction between Crizotinib and Disopyramide?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible and choose an alternative antiarrhythmic. If unavoidable, monitor ECG and electrolytes closely and consider reducing the disopyramide dose.
What other medicines interact with Crizotinib?
MediHelp also lists interactions of Crizotinib with, for example, Flibanserin, Lomitapide, Lonafarnib. The full list is on the Crizotinib page.
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