Drug interactions
Crizotinib + Elagolix
Severity: Moderate
Crizotinib and Elagolix: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Elagolix is a weak-to-moderate CYP3A4 inducer and a P-gp inhibitor, so its net effect on crizotinib is uncertain. Induction could lower crizotinib concentrations and reduce efficacy, while P-gp inhibition could raise them.
What this interaction means in plain words
Crizotinib and Elagolix can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Crizotinib belongs to Oncology; Elagolix belongs to Musculoskeletal.
Why it happens
Opposing effects of CYP3A4 induction and P-gp inhibition by elagolix on crizotinib exposure.
What to do
Monitor clinical response and crizotinib adverse effects. Adjust crizotinib dosing as needed if loss of efficacy or toxicity occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Crizotinib
- Crizotinib + Flibanserin Contraindicated
- Crizotinib + Lomitapide Contraindicated
- Crizotinib + Lonafarnib Contraindicated
- Crizotinib + Pimozide Contraindicated
- Crizotinib + Saquinavir Contraindicated
- Crizotinib + Thioridazine Contraindicated
Other interactions of Elagolix
- Cyclosporin + Elagolix Contraindicated
- Elagolix + Gemfibrozil Contraindicated
- Desogestrel-ethinyl estradiol + Elagolix Major
- Elagolix + Erythromycin Major
- Elagolix + Ethinyl estradiol-drospirenone Major
- Elagolix + Ethinyl estradiol-levonorgestrel Major
Frequently asked questions
Can I take Crizotinib with Elagolix?
MediHelp rates the interaction as moderate. Crizotinib and Elagolix can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Elagolix is a weak-to-moderate CYP3A4 inducer and a P-gp inhibitor, so its net effect on crizotinib is uncertain. Induction could lower crizotinib concentrations and reduce efficacy, while P-gp inhibition could raise them.
How serious is the interaction between Crizotinib and Elagolix?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor clinical response and crizotinib adverse effects. Adjust crizotinib dosing as needed if loss of efficacy or toxicity occurs.
What other medicines interact with Crizotinib?
MediHelp also lists interactions of Crizotinib with, for example, Flibanserin, Lomitapide, Lonafarnib. The full list is on the Crizotinib page.
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