Drug interactions
Crizotinib + Leuprolide
Severity: Moderate
Crizotinib and Leuprolide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Androgen deprivation therapy with leuprolide can prolong the QT interval, and crizotinib also prolongs QT and causes bradycardia. Together they may increase the risk of torsades de pointes.
What this interaction means in plain words
Crizotinib and Leuprolide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Crizotinib belongs to Oncology; Leuprolide belongs to Endocrine.
Why it happens
Additive pharmacodynamic QT prolongation.
What to do
Obtain baseline and periodic ECGs and monitor potassium and magnesium. Reduce or interrupt crizotinib if QTc becomes markedly prolonged.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Leuprolide
- Leuprolide + Pimozide Contraindicated
- Leuprolide + Thioridazine Contraindicated
- Amisulpride + Leuprolide Major
- Arsenic trioxide + Leuprolide Major
- Artemether / lumefantrine + Leuprolide Major
- Disopyramide + Leuprolide Major
Other interactions of Crizotinib
- Crizotinib + Flibanserin Contraindicated
- Crizotinib + Lomitapide Contraindicated
- Crizotinib + Lonafarnib Contraindicated
- Crizotinib + Pimozide Contraindicated
- Crizotinib + Saquinavir Contraindicated
- Crizotinib + Thioridazine Contraindicated
Frequently asked questions
Can I take Crizotinib with Leuprolide?
MediHelp rates the interaction as moderate. Crizotinib and Leuprolide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Androgen deprivation therapy with leuprolide can prolong the QT interval, and crizotinib also prolongs QT and causes bradycardia. Together they may increase the risk of torsades de pointes.
How serious is the interaction between Crizotinib and Leuprolide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain baseline and periodic ECGs and monitor potassium and magnesium. Reduce or interrupt crizotinib if QTc becomes markedly prolonged.
What other medicines interact with Leuprolide?
MediHelp also lists interactions of Leuprolide with, for example, Pimozide, Thioridazine, Amisulpride. The full list is on the Leuprolide page.
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