Drug interactions
Crizotinib + Nintedanib
Severity: Moderate
Crizotinib and Nintedanib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Crizotinib inhibits P-glycoprotein, and nintedanib is a P-gp substrate, so nintedanib exposure may rise. This could increase gastrointestinal effects, liver enzyme elevations and bleeding.
What this interaction means in plain words
Crizotinib and Nintedanib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Crizotinib belongs to Oncology; Nintedanib belongs to Oncology.
Why it happens
P-gp inhibition by crizotinib reduces efflux and clearance of nintedanib.
What to do
Monitor liver function tests and tolerability, and manage adverse effects with dose reduction or interruption of nintedanib.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Crizotinib
- Crizotinib + Flibanserin Contraindicated
- Crizotinib + Lomitapide Contraindicated
- Crizotinib + Lonafarnib Contraindicated
- Crizotinib + Pimozide Contraindicated
- Crizotinib + Saquinavir Contraindicated
- Crizotinib + Thioridazine Contraindicated
Other interactions of Nintedanib
- Amiodarone + Nintedanib Moderate
- Apixaban + Nintedanib Moderate
- Argatroban + Nintedanib Moderate
- Azithromycin + Nintedanib Moderate
- Carbamazepine + Nintedanib Moderate
- Carvedilol + Nintedanib Moderate
Frequently asked questions
Can I take Crizotinib with Nintedanib?
MediHelp rates the interaction as moderate. Crizotinib and Nintedanib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Crizotinib inhibits P-glycoprotein, and nintedanib is a P-gp substrate, so nintedanib exposure may rise. This could increase gastrointestinal effects, liver enzyme elevations and bleeding.
How serious is the interaction between Crizotinib and Nintedanib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor liver function tests and tolerability, and manage adverse effects with dose reduction or interruption of nintedanib.
What other medicines interact with Crizotinib?
MediHelp also lists interactions of Crizotinib with, for example, Flibanserin, Lomitapide, Lonafarnib. The full list is on the Crizotinib page.
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