Drug interactions
Crizotinib + Pacritinib
Severity: Major
Crizotinib and Pacritinib: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pacritinib is a CYP3A4 substrate, and crizotinib may increase its exposure. Pacritinib can cause QT prolongation, bleeding and diarrhea, which could be amplified.
What this interaction means in plain words
Crizotinib and Pacritinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Crizotinib belongs to Oncology; Pacritinib belongs to Oncology.
Why it happens
Crizotinib inhibits CYP3A4 metabolism of pacritinib, with possible additive QT effects.
What to do
Avoid the combination if possible. If used, monitor ECG, electrolytes and bleeding, and watch for pacritinib toxicity.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Crizotinib
- Crizotinib + Flibanserin Contraindicated
- Crizotinib + Lomitapide Contraindicated
- Crizotinib + Lonafarnib Contraindicated
- Crizotinib + Pimozide Contraindicated
- Crizotinib + Saquinavir Contraindicated
- Crizotinib + Thioridazine Contraindicated
Other interactions of Pacritinib
- Clarithromycin + Pacritinib Contraindicated
- Ketoconazole + Pacritinib Contraindicated
- Pacritinib + Posaconazole Contraindicated
- Pacritinib + Voriconazole Contraindicated
- Amiodarone + Pacritinib Major
- Carbamazepine + Pacritinib Major
Frequently asked questions
Can I take Crizotinib with Pacritinib?
MediHelp rates the interaction as major. Crizotinib and Pacritinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Pacritinib is a CYP3A4 substrate, and crizotinib may increase its exposure. Pacritinib can cause QT prolongation, bleeding and diarrhea, which could be amplified.
How serious is the interaction between Crizotinib and Pacritinib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination if possible. If used, monitor ECG, electrolytes and bleeding, and watch for pacritinib toxicity.
What other medicines interact with Crizotinib?
MediHelp also lists interactions of Crizotinib with, for example, Flibanserin, Lomitapide, Lonafarnib. The full list is on the Crizotinib page.
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