Drug interactions
Crofelemer + Fexofenadine
Severity: Minor
Crofelemer and Fexofenadine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Crofelemer acts locally in the gut and could theoretically inhibit intestinal transporters involved in fexofenadine absorption. Systemic exposure to crofelemer is negligible and no clinically important change in fexofenadine exposure is established.
What this interaction means in plain words
Crofelemer and Fexofenadine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Crofelemer belongs to Gastrointestinal Tract; Fexofenadine belongs to Respiratory.
Why it happens
Possible local gut inhibition of OATP1A2 and MRP2 transporters; the effect is not established clinically.
What to do
No dose adjustment is needed; monitor for reduced or increased antihistamine response if symptoms change.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Fexofenadine
- Danicopan + Fexofenadine Moderate
- Erdafitinib + Fexofenadine Moderate
- Fexofenadine + Glecaprevir / pibrentasvir Moderate
- Fexofenadine + Grapefruit Moderate
- Fexofenadine + Juice Moderate
- Acrivastine + Fexofenadine Minor
Other interactions of Crofelemer
- Crofelemer + Ergotamine Moderate
- Alfuzosin + Crofelemer Minor
- Amiodarone + Crofelemer Minor
- Apixaban + Crofelemer Minor
- Aprepitant + Crofelemer Minor
- Armodafinil + Crofelemer Minor
Frequently asked questions
Can I take Crofelemer with Fexofenadine?
MediHelp rates the interaction as minor. Crofelemer and Fexofenadine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Crofelemer acts locally in the gut and could theoretically inhibit intestinal transporters involved in fexofenadine absorption. Systemic exposure to crofelemer is negligible and no clinically important change in fexofenadine exposure is established.
How serious is the interaction between Crofelemer and Fexofenadine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is needed; monitor for reduced or increased antihistamine response if symptoms change.
What other medicines interact with Fexofenadine?
MediHelp also lists interactions of Fexofenadine with, for example, Danicopan, Erdafitinib, Glecaprevir / pibrentasvir. The full list is on the Fexofenadine page.
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