Drug interactions
Crofelemer + Modafinil
Severity: Minor
Crofelemer and Modafinil: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Crofelemer is minimally absorbed and inhibits CYP3A4 mainly in the gut, so the effect on modafinil exposure is likely small. Any clinical consequence is probably limited.
What this interaction means in plain words
Crofelemer and Modafinil have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Crofelemer belongs to Gastrointestinal Tract; Modafinil belongs to Central Nervous System.
Why it happens
Possible intestinal CYP3A4 inhibition by crofelemer; systemic effect unlikely due to minimal absorption.
What to do
No routine dose change is needed. Monitor for modafinil adverse effects such as headache, anxiety or insomnia.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Modafinil
Other interactions of Crofelemer
- Crofelemer + Ergotamine Moderate
- Alfuzosin + Crofelemer Minor
- Amiodarone + Crofelemer Minor
- Apixaban + Crofelemer Minor
- Aprepitant + Crofelemer Minor
- Armodafinil + Crofelemer Minor
Frequently asked questions
Can I take Crofelemer with Modafinil?
MediHelp rates the interaction as minor. Crofelemer and Modafinil have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Crofelemer is minimally absorbed and inhibits CYP3A4 mainly in the gut, so the effect on modafinil exposure is likely small. Any clinical consequence is probably limited.
How serious is the interaction between Crofelemer and Modafinil?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine dose change is needed. Monitor for modafinil adverse effects such as headache, anxiety or insomnia.
What other medicines interact with Modafinil?
MediHelp also lists interactions of Modafinil with, for example, Lenacapavir, Leniolisib, Lorlatinib. The full list is on the Modafinil page.
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