Drug interactions
Crofelemer + Ruxolitinib
Severity: Minor
Crofelemer and Ruxolitinib: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Crofelemer is minimally absorbed and may inhibit CYP3A4 only in the gut, so any rise in ruxolitinib exposure is likely small. Clinical relevance is limited.
What this interaction means in plain words
Crofelemer and Ruxolitinib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Crofelemer belongs to Gastrointestinal Tract; Ruxolitinib belongs to Oncology.
Why it happens
Possible intestinal CYP3A4 inhibition by crofelemer; systemic effect is unlikely because of minimal absorption.
What to do
No dose change is needed; monitor blood counts as usual for ruxolitinib therapy.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Ruxolitinib
Other interactions of Crofelemer
- Crofelemer + Ergotamine Moderate
- Alfuzosin + Crofelemer Minor
- Amiodarone + Crofelemer Minor
- Apixaban + Crofelemer Minor
- Aprepitant + Crofelemer Minor
- Armodafinil + Crofelemer Minor
Frequently asked questions
Can I take Crofelemer with Ruxolitinib?
MediHelp rates the interaction as minor. Crofelemer and Ruxolitinib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Crofelemer is minimally absorbed and may inhibit CYP3A4 only in the gut, so any rise in ruxolitinib exposure is likely small. Clinical relevance is limited.
How serious is the interaction between Crofelemer and Ruxolitinib?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is needed; monitor blood counts as usual for ruxolitinib therapy.
What other medicines interact with Ruxolitinib?
MediHelp also lists interactions of Ruxolitinib with, for example, Atazanavir, Ceritinib, Chloramphenicol. The full list is on the Ruxolitinib page.
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