Drug interactions
Dacomitinib + Metoclopramide
Severity: Major
Dacomitinib and Metoclopramide: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dacomitinib is a strong CYP2D6 inhibitor and can raise metoclopramide concentrations, which are partly cleared by CYP2D6. Higher exposure increases the risk of extrapyramidal symptoms, tardive dyskinesia, sedation and restlessness.
What this interaction means in plain words
Dacomitinib and Metoclopramide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Dacomitinib belongs to Oncology; Metoclopramide belongs to Gastrointestinal Tract.
Why it happens
Strong inhibition of CYP2D6-mediated metoclopramide metabolism increases plasma levels.
What to do
Reduce the metoclopramide dose in line with its labeling for strong CYP2D6 inhibitors, or choose another antiemetic. Monitor for extrapyramidal symptoms and sedation.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Metoclopramide
Other interactions of Dacomitinib
- Dacomitinib + Thioridazine Contraindicated
- Amitriptyline + Dacomitinib Major
- Atomoxetine + Dacomitinib Major
- Brexpiprazole + Dacomitinib Major
- Clomipramine + Dacomitinib Major
- Dacomitinib + Desipramine Major
Frequently asked questions
Can I take Dacomitinib with Metoclopramide?
MediHelp rates the interaction as major. Dacomitinib and Metoclopramide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Dacomitinib is a strong CYP2D6 inhibitor and can raise metoclopramide concentrations, which are partly cleared by CYP2D6. Higher exposure increases the risk of extrapyramidal symptoms, tardive dyskinesia, sedation and restlessness.
How serious is the interaction between Dacomitinib and Metoclopramide?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Reduce the metoclopramide dose in line with its labeling for strong CYP2D6 inhibitors, or choose another antiemetic. Monitor for extrapyramidal symptoms and sedation.
What other medicines interact with Metoclopramide?
MediHelp also lists interactions of Metoclopramide with, for example, Amantadine, Amoxapine, Antipsychotics (e.g., haloperidol). The full list is on the Metoclopramide page.
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